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Experiments were performed at room temperature with glass pipettes (4-5M resistance) filled with the intracellular solution comprising 140 mM CsMeSO 3 , 4 mM NaCl, 1 mM MgCl 2 , 1 mM EGTA, 5 mM HEPES, 2 mM MgATP, and 0.6 mM NaGTP, pH = 7.4 (CsOH)

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This synergy between IGF-1 and GH is crucial for maintaining energy balance and supporting growth processes

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We also confirmed that the association of rs10305420 with GLP1 medication efficacy cannot be accounted for by T2D or smoking status (Supplementary Information and Supplementary Tables 7 and 8)